Postdoctoral Research Fellowship in Single Cell Genomics, drug resistance in cancer is available at the UBC Off-Campus Hospital Sites, University of British Columbia.
Type: Full time
Requisition ID: JR11842
Theme: Single Cell Genomics, drug resistance in cancer
Laboratory/Department: Aparicio Laboratory | Department of Pathology and Laboratory Medicine | Faculty of Medicine (Samuel Aparicio)
The laboratory seeks a highly-motivated postdoc fellow (PDF) with strong leadership ability, expertise in single-cell genomics and transcriptomics, and strong molecular biology credentials. The selected applicant will work under the guidance of Dr. Samuel Aparicio. The position's start date is flexible.
The Aparicio lab is developing new single-cell genome and transcriptome methods for tracking clonal trajectories at the single-cell level in patient tissues and patient-derived xenografts (PDX). The Aparicio lab is developing new single-cell genome and transcriptome methods for tracking clonal trajectories in patients and patient-derived xenografts at single-cell levels. The program works closely with UBC statistics and computer science departments and the New York Genome Center NY on developing new models for single-cell data and cancer evolution.
- Provide leadership, strategic direction, and translational research on single-cell genomics, transcriptomics, and CRISPR methods.
- Design and implement a research plan to investigate the clonal dynamics in human cancer through single-cell methods.
- Conduct in vivo testing and characterization of drugs, small molecules, knockouts, or antibodies in relevant PDX animal models.
- Design and conduct animal experiments.
- Encourage collaborations and work jointly with academic, industry, clinical, and other partners.
- Scientifically document lab experiments, data analysis, and interpretations.
- Write manuscripts and present results.
- Discover funding opportunities and write/assist with grant proposals
- Mentor junior trainees/students.
Required Qualification: following criteria will be considered -
- Ph.D. in biology, molecular biology, cell biology, biochemistry, genomics, genetics, or a similar field.
- Solid scientific and technical background
- Excellent written/oral communication and organizational skills.
- Proven track record and at least 2-3 first-author publications in reputable journals (Preference).
- Proficiency in disciplines, as mentioned earlier.
- Experience with cancer research.
- Familiarity with testing/characterizing small molecules or drugs in vivo is preferred.
- Expertise and hands-on experience in animal studies (design, handling, breeding, tissue collection, histology, and analyses).
- Experience with bioinformatics methodologies to biological data and familiarity with handling genomics data.
- Experience and a strong track record with extensive drug target screening, single-cell methods, and PDX mouse models (preferable).
Interested candidates should submit a cover letter outlining their research interests, curriculum vitae, and the names of three referees willing to provide reference letters.
Deadline: Not Mentioned