Asked : 23 Apr 2024 Health
By : Amit Kumar
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Answered : 23 Apr 2024
By : Editor CoAxial
Diabetes mellitus (T2DM) is mainly caused by environmental influence, microbial infection, genetic, immune system dysfunction, and mental factors that result in insufficient insulin secretion and insulin resistance. The pathogenesis of T2DM is mainly including insulin resistance, impaired pancreatic β-cells function, obesity, oxidative stress and genetic susceptibility. Among them, it is considered that impaired pancreatic β-cell function and insulin resistance are t
[ + ]Answered : 23 Apr 2024
By : Editor CoAxial
Type 2 Diabetes mellitus (T2DM) is a complex, chronic disease of glucose metabolism which eventually can adversely affect the functions of vital organs of the human body and is responsible for millions of fatalities every year globally. According to the International Diabetes Federation (IDF), the number of global diabetic patients in 2019 was estimated to be 463 million, which will increase to 578 million by 2030 and 700 million by 2045.
Diabetes mellitus (T2DM) is mainly caused by environmental influence, microbial infection, genetic, immune system dysfunction, and mental factors that result in insufficient insulin secretion and insulin resistance. The pathogenesis of T2DM is mainly includes insulin resistance, impaired pancreatic β-cells function, obesity, oxidative stress and genetic susceptibility. Among them, it is considered that impaired pancreatic β-cell function and insulin resistance are the primary pathophysiological changes of T2DM. Therefore efficiency of insulin-mediated glucose uptake and utilization by skeletal muscle, adipocyte and liver is decreased. The currently available treatments are effective to some extent, but their efficacy to lower blood glucose levels for a longer duration is low, thus requiring a daily high dosage to control the blood glucose levels.
The discovery of long-acting antidiabetic drugs, which may improve insulin resistance and enable oral administration of drugs are crucial for clinical need.
Answered : 23 Apr 2024
By : Editor CoAxial
the number of global diabetic patients in 2019 was estimated to be 463 million, which will increase to 578 million by 2030 and 700 million by 2045.
Asked : 23 Apr 2024 Health
By : Editor CoAxial
What is Type 2 Diabeties?
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